Esterase catalyzed regio-and enantio-selective hydrolysis of substituted carboxylates

Article abstract of DOI:10.1246/cl.1997.741

Optically active α-substituted carboxylic acid derivatives were obtained with regio-and enantio-selective hydrolysis catalyzed by esterase from Pseudomonas putida MR-2068. Substrate specificities were summarized in empirical rule to predict the enantiopreferences of the esterase. High regio-selectivities were also discussed with binding models.