Synthesis and cytotoxicity of silyl- and carbonyl-substituted isoxazoles

Article abstract of DOI:10.1023/A:1002833119576

We have obtained various diphenylmethylsilyl- and carbonyl-substituted isoxazoles by [2+3]-dipolar cycloaddition of nitrile oxides to diphenylmethylsilyl-, hydroxymethyl-, methoxymethyl-, and ethoxycarbonylacetylenes. We have observed that the isoxazoles obtained exhibit moderate cytotoxicity relative to the HT-1080 and MG-22A cell lines. The highest activity level is displayed by 3-methyl-5-diphenylmethylsilylisoxazole.

Full text of DOI:10.1023/A:1002833119576

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