Potential Central Nervous System Active Agents. 1. Synthesis of Aromatic N-Benzyl Amides

Article abstract of DOI:10.1021/je00030a035

The preparation and spectral properties (IR, MS, NMR) are given for 18 aromatic N-benzyl amides, variously substituted on the acyl part, including four new ones and an (E)-cinnamide derivative.The amides were prepared by heating the appropriate N-benzylammonium salt in o-xylene, or from the reaction of the corresponding acid chloride with benzylamine.The occurrence of an intense peak in their mass spectra, which corresponds to the loss of the N-acyl substituent without hydrogen transfer, is reported.