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In summary, we have reported a selective, relatively mild and
fully optimised methodology for the hydration of organonitriles
in water, without the use of hydration-promoting additives such
as oximes and hydroxylamines. In situ formation of a
[Pd(OAc)2bipy] complex catalyses the transformation of a wide
array of aliphatic and aromatic nitriles into their primary amide
products in excellent yields. We believe our method successfully
combines simplicity with synthetic utility.
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We thank the Engineering and Physical Sciences Research
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support.
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