Studies on Ca2+ channel antagonists. 5-[(3,4-dimethoxyphenethyl)methylamino]-2-)3,4- dimethoxyphenyl)-2-isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil

DOI: 10.1021/jm00159a040

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Journal of Medicinal Chemistry p. 1789 - 1792 (1986)

Update date:2022-08-02

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Authors:

Theodore

Nelson Nelson

Zobrist Zobrist

et al. et al.

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Article abstract of DOI:10.1021/jm00159a040

Reduction of 1 (verapamil) afforded amine, which was converted with thiophosgene to isothiocyanate 3, a chemoaffinity ligand for Ca²⁺ channels. Compound 3 showed concentration-dependent negative inotropic effects in rat right myocardial ventric

Full text of DOI:10.1021/jm00159a040

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