Studies on Ca2+ channel antagonists. 5-[(3,4-dimethoxyphenethyl)methylamino]-2-)3,4- dimethoxyphenyl)-2-isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil

Article abstract of DOI:10.1021/jm00159a040

Reduction of 1 (verapamil) afforded amine, which was converted with thiophosgene to isothiocyanate 3, a chemoaffinity ligand for Ca²⁺ channels. Compound 3 showed concentration-dependent negative inotropic effects in rat right myocardial ventric