Journal of Medicinal Chemistry p. 1789 - 1792 (1986)
Update date:2022-08-02
Topics:
Theodore
Nelson
Zobrist
et al.
Reduction of 1 (verapamil) afforded amine, which was converted with thiophosgene to isothiocyanate 3, a chemoaffinity ligand for Ca2+ channels. Compound 3 showed concentration-dependent negative inotropic effects in rat right myocardial ventric
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