A SYNTHETIC APPROACH TO (+)-THIENAMYCIN FROM METHYL (R)-3-HYDROXYBUTANOATE. A NEW ENTRY TO (3R, 4R)-3--4-ACETOXY-2-AZETIDINONE

DOI: 10.1246/cl.1985.651

Source and publish data:

Chemistry Letters p. 651 - 654 (1985)

Update date:2022-08-11

Topics:

Authors:

Chiba, Toshiyuki

Nakai, Takeshi

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Article abstract of DOI:10.1246/cl.1985.651

A new entry to the O-silylated form of the title azetidinone, a well-established key intermediate for thienamycin synthesis, is described which relies on the stereocontrolled transformation of the 2-azetidinone obtained via the condensation of methyl (R)-3-hydroxybutanoate with the N-silylimine of trimethylsilylpropynal.

Full text of DOI:10.1246/cl.1985.651

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