A SYNTHETIC APPROACH TO (+)-THIENAMYCIN FROM METHYL (R)-3-HYDROXYBUTANOATE. A NEW ENTRY TO (3R, 4R)-3--4-ACETOXY-2-AZETIDINONE

Article abstract of DOI:10.1246/cl.1985.651

A new entry to the O-silylated form of the title azetidinone, a well-established key intermediate for thienamycin synthesis, is described which relies on the stereocontrolled transformation of the 2-azetidinone obtained via the condensation of methyl (R)-3-hydroxybutanoate with the N-silylimine of trimethylsilylpropynal.