Beilstein Journal of Organic Chemistry p. 1950 - 1956 (2017)
Update date:2022-08-11
Topics:
Howard, Joseph L.
Nicholson, William
Sagatov, Yerbol
Browne, Duncan L.
Solventless mechanochemical synthesis represents a technique with improved sustainability metrics compared to solvent-based processes. Herein, we describe a methodical process to run one solventless reaction directly into another through multistep mechanochemistry, effectively amplifying the solvent savings. The approach has to consider the solid form of the materials and compatibility of any auxiliary used. This has culminated in the development of a two-step, one-jar protocol for heterocycle formation and subsequent fluorination that has been successfully applied across a range of substrates, resulting in 12 difluorinated pyrazolones in moderate to excellent yields.
View MoreNanjing Raise Pharmatech Co., Ltd
website:http://www.raisechem.com
Contact:+86-25-58649566
Address:B381,No.606,Ningliu Road,Jiangbei New Area,Nanjing,Jiangsu Province,China
Chengdu Sino-Strong Pharmaceutical Co.,Ltd.
website:http://www.sino-strong.com.cn
Contact:+86-28-82666753
Address:459 West haike road,Cross-straits technological industry park, Wenjiang district,Chengdu, P.R.China
Refine Chemicals Science & Technology Technology Developing Co., Ltd.
Contact:+86-22-87899130
Address:No.12,west keyan road,Tianjin City
TAIZHOU XINGCHENG CHEMPHARM CO.,LTD.
Contact:0086-0576-88551200,88886292 ,88880039
Address:B Area. 10 Floor.Yaodadasha. 289#.Shifu Road.Taizhou.Zhejiang.China
Contact:86-516-66656369
Address:The west road of Huaihai, Xuzhou, China
Doi:10.1021/cm101677x
(2010)Doi:10.1023/B:RUCB.0000011886.03785.bd
(2003)Doi:10.1039/c9sc02882j
(2019)Doi:10.1002/prac.19823240627
(1982)Doi:10.1016/j.ejmech.2020.112078
(2020)Doi:10.1007/BF00913083
(1963)