Improved synthesis of pyrrolo[1,2-c]pyrimidine and derivatives

Article abstract of DOI:10.1016/0040-4039(96)00812-X

An improved synthesis of pyrrolo[1,2-c]pyrimidine derivatives by cyclocondensation of pyrrole-2-carboxaldehydes with tosylmethyl isocyanide followed by desulfonylation of the resulting 2-tosylpyrrolo[1,2-c]- pyrimidines with sodium amalgam is described.