Analogues of Cisplatin Derived from Diaminodeoxytetritols. Synthesis and Activity against the ADJ/PC6 Plasmacytoma in Mice

Article abstract of DOI:10.1021/jm00124a004

Four new analogues of the anticancer drug cisplatin have been prepared that contain a diaminodideoxytetritol derivative as the amine ligand moiety, and their acitivities have been measured against the ADJ/PC6 plasmacytoma in mice.Two of these compounds, the enantiomers of cis-dichloro(1,4-diamino-1,4-dideoxy-2,3-O-isopropylidenethreitol)platinum(II), show a higher TI value than cisplatin when administered by intraperitoneal injection and, importantly, show significant antitumor acitivity when administered orally.