Efficient Enantioselective Synthesis of the Antitumor Agent Sarkomycin

DOI: 10.1021/jo01292a053

Source and publish data:

Journal of Organic Chemistry p. 752 - 754 (1980)

Update date:2022-08-11

Topics:

Authors:

Boeckman, Robert K.

Naegely, Paul C.

Arthur, Samuel D.

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Article abstract of DOI:10.1021/jo01292a053

An efficient total synthesis of (+/-)-sarkomycin (1) is described via bicyclic lactone 8.Preparation of a key precursor (R)-(+)-6 via an asymmetric Diels-Alder reaction affords the correct enantiomer for the preparation of natural (R)-(-)-sarkomycin (1) in high optical yield.

Full text of DOI:10.1021/jo01292a053

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