
Journal of Organic Chemistry p. 752 - 754 (1980)
Update date:2022-08-11
Topics:
Boeckman, Robert K.
Naegely, Paul C.
Arthur, Samuel D.
An efficient total synthesis of (+/-)-sarkomycin (1) is described via bicyclic lactone 8.Preparation of a key precursor (R)-(+)-6 via an asymmetric Diels-Alder reaction affords the correct enantiomer for the preparation of natural (R)-(-)-sarkomycin (1) in high optical yield.
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