Efficient Enantioselective Synthesis of the Antitumor Agent Sarkomycin

DOI: 10.1021/jo01292a053

Source and publish data:

Journal of Organic Chemistry p. 752 - 754 (1980)

Update date:2022-08-11

Topics:

Authors:

Boeckman, Robert K.

Naegely, Paul C.

Arthur, Samuel D.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo01292a053

An efficient total synthesis of (+/-)-sarkomycin (1) is described via bicyclic lactone 8.Preparation of a key precursor (R)-(+)-6 via an asymmetric Diels-Alder reaction affords the correct enantiomer for the preparation of natural (R)-(-)-sarkomycin (1) in high optical yield.

Full text of DOI:10.1021/jo01292a053

Products guided by the article

Product name:Sarkomycin

Cas No:11031-48-4

R&D Labs maybe for 11031-48-4

SINO Industries Company Limited(expird)

Contact:86-29-85369724

Address:No.111, Jiefang Road, Xi’an, China
Chinapeptides Co,. Ltd

Contact:+86-021-50792271

Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202
Jiangxi Global Natural Spice Co., Ltd.

website:https://www.jxhqxl.com/

Contact:+86-796-8106598

Address:No.89, Wenshan Road,South Industrial Park, Jishui County,Jiangxi Province
JADECHEM NINGBO CO.,LTD.

Contact:+86-574-89075960

Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
Jiaxing Barton Chemicals

website:http://www.chinabarton.com

Contact:+86-573-82719618

Address:No. 162 Fumin Road, Honghe Town,

Relevant to this article

Spectroscopic studies of bimetallic complexes derived from tridentate or tetradentate Schiff bases of some di- and tri-valent transition metals

Doi:10.1016/j.saa.2005.09.010
(2006)
Synthesis and structural characterization of tris(2-pyridonyl)methyl complexes of zinc and thallium: A new class of metallacarbatranes and a monovalent thallium alkyl compound

Doi:10.1039/c3dt52163j
(2013)
Beyond PEG2000: Synthesis and functionalisation of monodisperse pegylated homostars and clickable bivalent polyethyleneglycols

Doi:10.1002/chem.201402186
(2014)
Synthesis of (E)- and (Z)-5-(bromomethylene)furan-2(5H)-one by bromodecarboxylation of (E)-2-(5-oxofuran-2(5H)-ylidene)acetic acid

Doi:10.1080/00397910500522108
(2006)
Maternal obesity results in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fatty acid with anti-inflammatory and insulin-sensitizing properties

Doi:10.1096/fj.201802444R
(2019)
Structural competition between hydrogen bonds and halogen bonds

Doi:10.1021/ja073201c
(2007)

Article Doi