Synthesis p. 369 - 370 (1992)
Update date:2022-08-17
Topics:
Schick, Hans
Ludwig, Ralf
Ethyl 2-bromoalkanoates react with zinc and succinic anhydride in dimethylformamide forming 2-substituted 1-ethyl hydrogen 3-oxoadipates (hexanedioates) isolable in a yield of 56 - 78percent.When subjected to decarboxylative saponification, they afford 4-oxoalkanoic acids in overall yields of 50 - 72percent
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Doi:10.1246/cl.1992.1345
(1992)Doi:10.1246/cl.2007.998
(2007)Doi:10.1021/ja01313a060
(1935)Doi:10.1016/j.bmcl.2018.04.001
(2018)Doi:10.1016/j.tetlet.2019.06.018
(2019)Doi:10.1016/j.tet.2016.04.011
(2016)
