Structure-Activity relationship of aliphatic compounds for nematicidal activity against pine wood nematode (Bursaphelenchus xylophilus)

Article abstract of DOI:10.1021/jf902575f

Nematicidal activity of aliphatic compounds was tested to determine a structure-activity relationship. There was a significant difference in nematicidal activity among functional groups. In a test with alkanols and 2E-alkenols, compounds with C₈-C₁₁ chain length showed 100% nematicidal activity against pine wood nematode, Bursaphelenchus xylophilus, at 0.5 mg/mL concentration. C₆-C₁₀ 2E-alkenals exhibited >95% nematicidal activity, but the other compounds with C ₁₁-C₁₄ chain length showed weak activity. Nematicidal activity of alkyl acetates with C₇-C₁₁ chain length was strong. Compounds belonging to hydrocarbons, alkanals, and alkanoic acetates showed weak activity at 0.5 mg/mL concentration. Nematicidal activity of active compounds was determined at lower concentrations. At 0.25 mg/mL concentration, whole compounds except C₈ alkanol, C₈ 2E-alkenol, and C₇ alkanoic acid showed >80% nematicidal activity. C ₉-C₁₁ alkanols, C₁₀-C₁₁ 2E-alkenols, C₈-C₉ 2E-alkenals, and C₉-C₁₀ alkanoic acids showed >80% nematicidal activity at 0.125 mg/mL concentration. Only C₁₁ alkanol exhibited strong nematicidal activity at 0.0625 mg/mL concentration, the lowest concentration that was tested. 2010 American Chemical Society.