Lithium amidotrihydroborate, a powerful new reductant. Transformation of tertiary amides to primary alcohols

DOI: 10.1016/0040-4039(96)00652-1

Source and publish data:

Tetrahedron Letters p. 3623 - 3626 (1996)

Update date:2022-08-28

Topics:

Authors:

Myers, Andrew G.

Yang, Bryant H.

Kopecky, David J.

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Article abstract of DOI:10.1016/0040-4039(96)00652-1

Lithium amidotrihydroborate (LiH₂NBH₃, LAB) is a new and highly nucleophilic reducing agent that is easily prepared by deprotonation of the commercial reagent borane-ammonia complex (H₂NBH₃) with n-BuLi in tetrahydrofuran (THF) at 0°C. LAB is found to be a superior reagent for the transformation of tertiary amides into the corresponding primary alcohols.

Full text of DOI:10.1016/0040-4039(96)00652-1

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