Polymer supported triazine based palladium complex catalyzed double carbonylation reaction of halo aryl compounds for the synthesis of α-ketoamides

Article abstract of DOI:10.1016/j.jorganchem.2018.12.008

Novel polystyrene incorporated Palladium (II) catalyst was developed and well characterized. The efficiency of the supported Pd(II) catalytic material was checked for double carbonylation reaction of 2° amines and aryl iodides to their corresponding α-ketoamides under high pressure reaction conditions. The reaction was carried out in 60 psi carbon monoxide pressure. An extensive variety of aryl iodides in combination with 2° amines in presence of carbon monoxide can produce the respective α-ketoamides with superb chemoselectivity. Effect of solvents, bases, time and amount of catalyst for the production of α-ketoamides were reported. This supported Pd(II)complex was highly catalytically active and recyclable. The developed catalytic material was regenerated by filtration. It could be recycled further six times with no such profound loss in its activity.

Full text of DOI:10.1016/j.jorganchem.2018.12.008

Accepted Manuscript
Polymer supported triazine based palladium complex catalyzed double carbonylation
reaction of halo aryl compounds for the synthesis of α-ketoamides
Sk Safikul Islam, Rostam Ali Molla, Sabyasachi Ta, Nasima Yasmin, Debasis Das, Sk
Manirul Islam
PII:
S0022-328X(18)30865-9
DOI:
https://doi.org/10.1016/j.jorganchem.2018.12.008
JOM 20665
Reference:
To appear in: Journal of Organometallic Chemistry
Received Date: 3 October 2018
Revised Date: 5 December 2018
Accepted Date: 6 December 2018
Please cite this article as: S.S. Islam, R.A. Molla, S. Ta, N. Yasmin, D. Das, S.M. Islam, Polymer
supported triazine based palladium complex catalyzed double carbonylation reaction of halo aryl
compounds for the synthesis of α-ketoamides, Journal of Organometallic Chemistry (2019), doi: https://
doi.org/10.1016/j.jorganchem.2018.12.008.
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ACCEPTED MANUSCRIPT
Polymer supported Triazine based Palladium complex catalyzed double carbonylation
reaction of Halo aryl compounds for the synthesis of α-ketoamides
Sk Safikul Islam,a Rostam Ali Molla,b Sabyasachi Ta, b Nasima Yasmin*a, Debasis Das*,b,
Sk. Manirul Islam*,c
aDepartment of Chemistry, Aliah University, Kolkata-700156,W.B, India.
bDepartment of Chemistry,University of Burdwan, Burdwan, , W.B., India
cDepartment of Chemistry,University of Kalyani, Kalyani, Nadia 741235, W.B., India.
Graphical Abstract:

ACCEPTED MANUSCRIPT
Polymer supported Triazine based Palladium complex catalyzed double
carbonylation reaction of Halo aryl compounds for the synthesis of α-
ketoamides
Sk Safikul Islam,a Rostam Ali Molla,b Sabyasachi Ta, b Nasima Yasmin*a, Debasis Das*,b,
Sk. Manirul Islam*,c
aDepartment of Chemistry, Aliah University, Kolkata-700156,W.B, India.
bDepartment of Chemistry,University of Burdwan, Burdwan, , W.B., India
cDepartment of Chemistry,University of Kalyani, Kalyani, Nadia 741235, W.B., India.
ABSTRACT
Novel polystyrene incorporated Palladium (II) catalyst was developed and well
characterized. The efficiency of the supported Pd(II) catalytic material was checked for
double carbonylation reaction of 2o amines and aryl iodides to their corresponding α-
ketoamides under high pressure reaction conditions. The reaction was carried out in 60 psi
carbon monoxide pressure. An extensive variety of aryl iodides in combination with 2o
amines in presence of carbon monoxide can produce the respective α-ketoamides with superb
chemoselectivity. Effect of solvents, bases, time and amount of catalyst for the production of
α-ketoamides were reported. This supported Pd(II)complex was highly catalytically active
and recyclable. The developed catalytic material was regenerated by filtration. It could be
recycled further six times with no such profound loss in its activity.
Key words: supported catalyst, palladium, carbonylation, aryl halides, α-ketoamides
* Author to whom correspondence should be addressed. Dr. Sk. Manirul Islam
Department of Chemistry, University of Kalyani ,Kalyani, Nadia, 741235, W.B., India
Phone: + 91- 33-2582-8750, Fax: 91-33-2582-8282, E-mail: manir65@rediffmail.com
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1. Introduction
α-Ketoamides are essential building blocks in synthetic drugs, biologically active
molecules, and pharmaceutical compounds [1-6]. In addition these compounds are used as
important fragments for the conversion of vary functional group [7-14]. α-Ketoamides can
also plays as an important role to formation of medicinally active molecules for example
tetrasubstituted 2-oxazolidin-4-one and 2-oxindoles [15-19]. Hence, establishing a common,
realistic, and efficient pathway to synthesis α-ketoamides having different functional groups
is of meaningful.
For homogeneous catalytic reactions, there are various methodologies have been invented to
overcome the problems like metal-contaminated crude products, recycling and catalyst
recovery [20-21]. Metal supported heterogeneous catalysts have several advantages such as
increasing the stability of the organic moieties, easy separation process; catalyst recovery as
well as heterogeneous Pd catalysts improved the efficiency of carbonylation reactions [22].
Pd catalysts in different supported material are extensively used in double carbonylation
reaction of various aromatic halides with CO (carbon monoxide) [23-29]. CO is used for
synthesis of different carbonyl substances like amides, carboxylic acids, aldehydes and
ketones since it is easily available and low-cost C1 source [30-40]. Amidst diverse CO
insertion processes, Pd catalyzed double carbonylation of aryl halides is a valuable strategy in
producing vital carbonyl substances [41-42].
In the literature numerous techniques have been recorded to reach their synthesis [43-
48] from which the catalysis of transition metal approaches have confirmed to the desired
compounds in great selectivity and very well yields. Although, a few number of examples
have been reported on the formation of α-ketoamides from aromatic halides and amines in
presence of pressurized carbon monoxide gas [49-55].
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For double carbonylation reaction there were numerous number of catalytic system was
reported such as Pd/C/PPh3 catalyst system [56], silica-incorporated polytitazane-palladium
(Ti–N–Pd) compound [57] and mesoporous silica supported palladium complexes [58].
However, some of the strategies in our excellence of knowledge have been reported for the
synthesis of α-ketoamides. Uozumi and co-workers [59] used Pd/PPh3 catalyst in presence of
a base, DABCO (1,4-diazabicyclo[2.2.2]octane) in preparing α-ketoamides
under
atmospheric CO pressure. However, the procedure is only valid to those aryl iodide
compounds without electron-withdrawing (EW) groups. Recently, Kondo and co-workers
developed an efficient Pd/PtBu3 catalyst system using DBU as base, for the production of α-
ketoamides with tremendous chemo-selectivity [60]. However, the using basic ligand is
frequently an issue when this ligand is used to a large scale development. In addition this,
there has been numerous disadvantage for the use of ambient pressure of CO for the synthesis
of α-ketoamides, likely due to poor reactivity of CO and less chemoselectivity [61]. Thus,
the progress of a fresh process in preparing α-ketoamides would be highly desirable. To get
rid from these serious issues heterogeneous palladium catalyst may be used. Heterogeneous
catalysts are commonly used in industrial process as they, can be purified from the mixture
simple technique, have a excellent thermal strength, and can be often reused and regenerated.
Herein we report a new methodologies for the synthesis of a polymer supported Pd(II)
catalyst that exhibits excellent activity for the synthesis of α-Ketoamide type compounds
with superb yields and high selectivities via twice carbonylation reaction of aryl iodides and
amines with carbon monoxide.
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2. Experimental
2.2 Preparation of catalyst
The preparation technique followed to get the Pd(II) complex is shown in Scheme 1.
The polymer complex was synthesised in three step process. At first in 5 ml toluene
imidazole (6.8 gm) and potassium iodide (0.1 gm) were dissolved in N2 atmosphere after that
the reaction mixture was heated to 400C. Then CH3ONa (5.4 gm) in methanol (10 ml) was
added drop by drop with continuous stirring for about 30 min to form imidazole salt. The
chloromethylated polystyrene (1.8 gm) in 15 ml acetonitrile was mixed to sodium imidazole
solution. Then the solution was continuously stirred at 650C for a time period of 48 hrs. The
imidazole functionalised polystyrene beads was washed by ethanol and dried at 400C.
In CH3CN (ACN) solvent, the imidazole salt of chloromethylated polystyrene (0.5
gm) and cyanuric chloride (0.184 gm, 1 mmol) were heated for 2.5 hrs at 1100C.The solid
product was obtained, washed by ACN and methanol respectively. Then the solid dried at
400C under vacuum.
This Polymer supported PImdCC-ligand (0.5 gm) and tBuONa (2.2mmol) in THF (15
mL) was treated with 9 wt. % palladium acetate for 40 min under continuous stirring. After
that solution was heated to reflux at 800C for 1 day. Thus, the palladium (II) catalyst
(PImdCC@Pd) was formed, filtered followed by washed with CH3OH and dried at a
temperature of 400C under vacuum.
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Scheme 1 Preparation of polymer incorporated palladium (II) catalyst.
2.3 General procedure for double carbonylation of aryliodides with amine
In a high-pressure reactor, aryl iodides (0.5 mmol), morpholine (0.5 mmol), K2CO3 (1 mmol),
PImdCC@Pd catalyst (50 mg) were mixed in 10 ml of toluene and then mixture was purged
with CO (60 Psi) before heating at 550C for 5 h. After that the reactor was cool to RT, the
excess carbon monoxide was release from the high pressure chamber. Then the reaction
mixture was extracted with aqueous sodium chloride (15 mL) and ethyl acetate (45 mL). The
organic compounds were mixed with EtOAc, and the solvent was removed by a rotary
evaporator. The desired compound was isolated. By column chromatography the crude
product was purified and yield was identified by 1H and 13C NMR.
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3. Results and Discussion
3.1 Characterization of the PImdCC@Pd Catalyst
Because of insoluble nature of supported palladium catalyst in all the commercially
available organic solvents, its study of structural examination was limited to its chemical
analysis, SEM-EDX,TGA, physicochemical properties, IR and UV-vis spectroscopic data.
The elemental data analysis of polymer support and the Pd bind catalyst was shown in Table
1. By AAS, Pd content in the polymeric catalyst was estimated which suggests that 4.56 wt%
of Pd present in the catalyst.
Table 1 Chemical composition of polymeric ligand and polymer incorporated catalyst.
Compound
PImdCC
colour
C%
H%
N%
metal%
-
Off white
72.75
5.16
9.44
PImdCC@
Pd
Light
69.47
4.67
8.55
4.56
yellow
The attachment modes of palladium metal onto the supported complex were
established by assessment of the Fourier-transform infrared spectroscopic data (fig. 1) of the
palladium incorporated catalyst on the polymer complex in several steps of its preparation
method. For PImdCC@Pd catalyst, the characteristic peaks of the C−H stretching vibration of
1
1
aromatic ring, symmetric and asymmetric of methylene at 3023 cm− and 2852 cm− and
1
2922cm− [62], respectively. In polymeric complex, the bands at ~ 1094 and ~3415 cm-1 have
been shown to the frequency of C-N and N-H stretching respectively which is slightly differ
from ligand. The spectra of the PImdCC@Pd shows one average to intense band around at
~1658 cm-1, that may be assigned to the vibration of stretching of C=O attached with the
polymer. The distinct bands observed at 1560 cm-1and 1447 cm-1 due to presence of triazine
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ring in the PImdCC complex. Therefore, it is rather difficult to making accurate assignments
to stretching frequency N-Pd in far IR region.
Fig.1. FT-IR Spectral data of polymer anchored ligand (a) PImdCC , (b) PImdCC@Pd
complex
In the diffuse reflectance method, the electronic spectrum of the polymer supported
PImdCC ligand and the immobilized PImdCC@Pd catalyst has been shown in fig.2. Diffuse
reflectance ultraviolet--visible spectral data of the PImdCC and PImdCC@Pd catalyst was
taken from 200 to 800 nm range. The Pd(II)metal complex showed the two absorption due to
the transition of n–π∗ and π –π∗ at 235 nm and 252 nm respectively [63]. The d-d transitions
were seen due to the absorption bands around 510 nm is assigned respectively [64].
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Fig. 2. DRS-UV-visible spectral data of the PImdCC and PImdCC@Pd catalyst
The SEM image of PImdCC (Fig. 3A) and supported PImdCC@Pd catalyst (Fig. 3B)
definitely show changes in morphology which happened on the polymer surface after
complexation on it. The EDX analysis of X-rays spectral data for PImdCC and PImdCC @Pd
catalyst are shown in Fig. 4A and B. The Energy dispersive spectroscopy analysis confirmed
that the palladium metal is attached over the polymeric surface.
Fig. 3. SEM images of polymer supported ligand (A) (PImdCC), (B) PImdCC @Pd complex
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Fig. 4. Energy Dispersive Spectroscopy data of polymeric ligand (PImdCC) (A) and
PImdCC @Pd complex (B)
Thermal strength of the supported complex was examined using TGA over a
0
0
temperature between 30–600 C at a rate of heating 10 C/min in N2 atmosphere. A TGA-
plot of the polymer incorporated PImdCC and PImdCC @Pd catalyst is shown in Fig. 5. The
thermal stability of the PImdCC@Pd catalyst is higher as compares to PImdCC ligand
obviously shown that the palladium metal loading to the surface of the polymeric complex.
0
The catalyst is stable upto 350 C temperature. Thermo gravimetric analysis proves that the
polymer supported PImdC@Pd catalyst decomposes at slightly higher temperature than the
polymeric ligand (PImdCC). This catalyst and its ligand are rapidly decomposed after 450 0C
temperature.
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Fig.5. TGA plots of the PImdCC and PImdCC @Pd complex.
3.2. Catalytic Activity of the PImdCC @Pd Catalyst
Since palladium supported catalysts show superb catalytic reactivity in a variety
of the important industrial processes and have been widely considered for C-C coupling [65],
therefore we determined to examine the reactivity of the PImdCC @Pd in the field of double
carbonylation of aryl iodides to α-Ketoamides. Preliminary studies paying attention on
probing the practicability of the catalytic reactions and to optimize the reaction conditions, it
could be applicable to a various aryl halides.
Scheme 2: Pd(II) catalyzed carbonylation reaction of aryl iodides.
In order to verify the action of the PImdCC @Pd, the double carbonylation of
aromatic iodides and morpholine in carbon monoxide atmosphere described in Scheme 2 was
performed. In this conversion aryl iodides were changes to α-Ketoamides under the reaction
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conditions. Quantitative transformation of aryl iodide to α-Ketoamides was performed by
utilizing Pd supported polymeric catalyst (PImdCC @Pd). The double carbonylation reaction
of aryl iodide and morpholine was done in the toluene solvent medium using K2CO3 as the
0
base. The reaction was done in a 50-ml high pressure autoclave at 55 C under 60 psi of
carbon monoxide pressure for 5h reaction time.
Preliminary analysis was carried out with iodobenzene as model substrate (scheme 3)
for the identification of the optimization conditions. The activity of palladium-catalyst
towards carbonylation reaction is monitored by a number of reaction parameters. Various
bases and solvents were checked to discover the suitable conditions of reaction (Table 2). So
as to recognize valuable reaction conditions for the promotion of Pd catalyzed carbonylation,
the transformation was checked under different time interval and temperatures (Table 3).
Scheme 3 Pd(II) supported polymer catalyzed carbonylation of of iodobenzene
Table 2 Effect of solvent and base on carbonylation of iodobenzene
Entry Base
Solvent
GC
Yield
(%)
1
2
3
4
EtONa
Dimethylformamide
Dimethylformamide
Dimethylformamide
dioxane
72
Na2CO3
K2CO3
EtONa
52
59
62
5
6
Na2CO3
K2CO3
dioxane
Toluene
73
94
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7
8
EtONa
Na2CO3
K2CO3
K2CO3
Toluene
PEG-600
PEG-600
Toluene
44
57
9
78
10a
trace
Reaction conditions: PhI (0.5 mmol), morpholine(0.5 mmol), Base (1.0 mmol), CO (60 psi),
PImdCC @Pd (50 mg), PPh3(30 mg), solvent (3.0 mL), 55 0C, 5 h. aabsence of PPh3.
To examine the importance of base for this catalytic transformation, a variety of bases
were screened (Table 2). Experimental results exhibit that inorganic bases are highly active
for the reaction. In a short time period, in presence of K2CO3 the reaction gives high yield.
0
We established that utilizing K2CO3 as base in toluene medium at 55 C gave 94%
conversion. The other bases like, Na2CO3 and EtONa were less effective compared to K2CO3,
and only afforded medium to moderate yield. To examine the effect of solvent and different
organic solvents were also checked for the carbonylation reaction of iodobenzene. The
reaction carried out in less polar aprotic solvent, toluene gives a maximum yield and shows
the most efficient solvent. With the utilization of other polar solvents like, dioxane and DMF
gave lesser yield. Therefore, toluene was taken as the solvent medium for this carbonylation
reaction.
Table 3 Effect of time and reaction temperature on double carbonylation
Entry
Temperature
Time(h)
Yield
(%)
84
(0C)
45
1
2
3
4
5
5
5
5
2
7
55
65
85
85
94
94
65
90
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Reaction conditions: PhI (0.5 mmol), morpholine (0.5 mmol), K2CO3 (1.0 mmol), CO (60
psi), PImdCC @Pd (50 mg), PPh3(30 mg), Toluene (3.0 mL).
It has been found that this carbonylation reaction was very sensitive to temperature of
the reaction medium. At temperature range 450C to 85 0C was applied for this reaction but it
0
has also been found that the temperature of 55 C was the ideal temperature for the novel
reaction (Table 3). The catalytic transformation was also done for various time interval ,
ranging from 2h to 7h and it showed that at 5h the conversion was 94% under the given
reaction condition.(Table 3)
Fig.6. Effect of catalyst loading on carbonylation of iodobenzene
The effect of quantity of the PImdCC@Pd catalyst on the production of yield for this
reaction was also examined (Fig 6). The catalyst amount was increased from 10 mg to 60 mg
in the reaction settled under optimization. The yield of the reaction increases as the amount of
active sites increases and maximum yield of 94% was obtained for 50 mg palladium catalyst.
Beyond 50 mg of catalyst loading to the reaction no such further conversion was observed.
Therefore, 50 mg of catalyst loading is the optimum amount of catalyst for the conversion of
the desired product.
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With help of this optimization, different derivatives of aryl iodide were transformed to their
corresponding α-ketoamides. In Table 4 the various substrate were tested and results are
summarized. To explore the substrate scope with different aryl iodides and amines these
protocol is very much important. As shown in scheme 2, double carbonylation of various
substituents aryl iodides and amines were carried out in the optimized condition and all the
reactant delivers well to excellent yields. The different position of reactants slightly
influences the double carbonylation reaction: p-iodotoluene (table 4, entries 2-3, 7-8).
Comparatively lower yields for 1-bromo-4-iodobenzene were found due to mixture of
products due to formation small amount amide side product (Table 4, entry 6, 10). The
substitutions on the aromatic ring of aryl iodides, which may either electron rich or electron
deficient moiety shows significant effect on the result of the catalytic reaction. Aryl halides
contain electron-withdrawing and electron-donating substituents, transformed to the
respective α-ketoamides with superb yields. Aryl iodides containing strong electron-releasing
moiety such as methyl and methoxy, produced in higher yields than 1-bromo-4-iodobenzene
due to presence of reactive bromide attached para to the iodide of the phenyl ring (Table 4,
entries 2-5 and 7-9). Reaction pathway may be similar to previous literatures report (55, 66-
67). Palladium metal is very stabilized by nitrogen enrich PImdCC support. These supported
Pd material is contain of active sites which are responsible for the double carbonylation
reactions. It is usually found that by oxidative addition of an aryl halide to the Pd(0) complex
gives an organopalladium halide species .After that the process will give an acylpalladium
halide, involves migratory insertion of a coordinated CO. It is observed that in presence of
CO (60 Psi) pressure the acylpalladium halide complex reacts with an amine (nucleophile)
and a base to to give α-ketoamides.
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Table 4 Polymer supported palladium (II) catalyzed carbonylation of aryl iodides.
Entry
1.
Aryl halides
Product
GC
Yield (%)
94/92a
2.
90/88a
85/84a
3.
4
84/82a
80/77a
64/62a
5.
6.
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7.
8.
92/90a
86/84a
88/85a
62/60a
9.
10.
Reaction conditions: PhI (0.5 mmol), morpholine (0.5 mmol), base (1.0 mmol), CO (60 psi),
PImdCC @Pd (50 mg), PPh3(30 mg), Toluene (3.0 mL), 55 0C, 5 h. a Isolated Yield (%).
Comparison with other reported catalytic system
The activity of the PImdCC@Pd(II) catalyst was shown outstanding performance in case of
carbonylation of iodobenzene and its derivatives. A relative study is shown in Table 5. This
polymer-anchored complex plays a significant role in this superb activity.
Table 5
Comparison of catalyst activity of the PImdCC@Pd catalyst in the formation of α-
ketoamides with various reported systems
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Entry
1.
Catalyst
Reaction
Conditions
Yield (%)
Ref.
61
Pd(OAc)2
Na2CO3,PEG-
400,CO(ballon),
RT
94
99
94
98
2.
3.
4
Pd-NHC
K2CO3,Dioxane,
P(CO 2.0 MPa);
90 °C; 5 h.
66
This Study
67
complex II
PImdCC@Pd
K2CO3,Toluene,
CO (60 psi),
PPh3, 55 0C, 5 h.
K3PO4, CO (20
atm), DMF (5.0
mL) at 900C,12
h.
mPMF–Pd0
Catalyst
Heterogeneity test
Hot-filtration test
To examine whether the catalytic reaction go through in a homogeneous or a
heterogeneous mode, hot-filtration method was applied in the double carbonylation of aryl
iodide. By simple filtration, the solid catalyst was separated after proceed the reaction
mixture (Scheme 3) for 2h, and the observed yield was 65%. The liquid reaction mixture part
was heating for another 3h it has been found that no transformation occurs. This ensures that
the reaction was not proceeding without the solid catalyst. Moreover, no proof for significant
leaching of Pd metal or decomposition of the supported catalyst was shown during the phase
of the reaction and no Pd was found by AAS data of the liquid phase of the reaction mixture
after elimination of the catalyst. Through the phase of carbonylation, the above study clearly
suggests that the Pd was not being leached out from the heterogeneous catalyst.
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Catalyst reusability
Separation process and reusability of the heterogeneous catalyst are very much
important in the carbonylation reactions. We checked the recyclability of the palladium
supported heterogeneous complex in the carbon monoxide insertion reaction of iodobenzene
(Fig. 7). Herein, aryl iodides (0.5 mmol), morpholine (0.5 mmol), K2CO3 (1 mmol),
PImdCC@Pd catalyst (50 mg) were mixed in 10 ml of toluene and then mixture was purged
with CO (60 Psi). The PImdCC@Pd catalyst was separated from reaction mixture by
centrifuged method after the reaction was completed. Then the catalyst was thoroughly
washed with distilled water and subsequently with other solvent like, acetone. The catalyst
0
dried in air at 40 C. After that, the recovered catalyst was used in carbonylation reaction
under optimal conditions for the next run. The heterogeneous PImdCC@Pd catalyst was
efficiently recycled up to six times with no loss in desired product yield under the same
reaction conditions.
Fig.7. Reusability test of PImdCC@Pd catalyst.
Conclusions
In conclusion, this work demonstrated that synthesis and characterization of polymer
incorporated Pd(II) complex and its successful application towards the synthesis of α-
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ketoamide. Electron-donating and electron withdrawing containing aryl iodide derivatives
can check and also various crucial factors such as temperature, bases and the nature of the
solvents are responsible for the transformation. The reaction system is extremely moisture
and air stable and the supported PImdCC@Pd complex was prepared easily from
commercially obtainable and low-priced materials as starting. However, with no efficient loss
in its catalytic activity the catalyst was reused for six more times. Moreover, this work is used
as a strategy to expand the possibility of other various organic conversions.
Acknowledgments
S.M.I. acknowledges the Department of Science and Technology, DST-SERB,
(Project No EMR/2016/004956), New Delhi, Govt. of India, Council of Scientific &
Industrial Research, CSIR, (Project No 02(0284)/16/EMR-II), Date: 06-12-2016; and
Technology, West Bengal (DST-WB, Sanction No. 811(sanc.)/ST/P/S&T/4G-8/2014 Dated:
04.01.2016) and Board of Research in Nuclear Sciences (BRNS), Govt. of India, Project
reference No: 37(2)/14/03/2018-BRNS/37003 for funding. SSI also acknowledges UGC, for
providing senior research fellowship (MANF-2015-17-WES-56540). NY acknowledges
Aliah University. RAM acknowledges The Department of Science & Technology (DST) for
their NPDF (PDF/2017/000218). RAM acknowledges The Department of Science &
Technology (DST) for his NPDF (PDF/2017/000218). We sincerely thank Department of
Chemistry of the University of Burdwan for infrastructural facilities. We acknowledge
Department of Science and Technology (DST) and University Grant Commission (UGC)
New Delhi, India for providing support to the Department of Chemistry, University of
Kalyani under PURSE, FIST and SAP program
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Research Highlights
Polymer supported Triazine based Palladium complex catalyzed double
carbonylation reaction of Halo aryl compounds for the synthesis of
ketoamides
α-
Sk Safikul Islam,a Rostam Ali Molla,b Sabyasachi Ta, b Nasima Yasmin*a, Debasis Das*,b, Sk.
Manirul Islam*,c
aDepartment of Chemistry, Aliah University, Kolkata-700156,W.B, India.
bDepartment of Chemistry,University of Burdwan, Burdwan, , W.B., India
cDepartment of Chemistry,University of Kalyani, Kalyani, Nadia 741235, W.B., India.
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•
•
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Polystyrene supported Pd complex was synthesize
The catalyst was characterized by FT-IR, Uv, SEM and TGA
The catalyst was tested for double carbonylation reaction
Supported catalyst is reusable upto 6 times