Tandem N-acyliminium-Michael addition reaction. An efficient total synthesis of the quinolizidine alkaloids (+/-)-myrtine and (+/-)-lasubine II

Article abstract of DOI:10.1016/S0040-4039(00)73547-7

A short and efficient preparation of the quinolizidine alkaloids (±)-lasubine II (1) and (±)-myrtine (2) is described featuring the tandem N-acyliminium ion-Michael addition of 2-trimethylsilyloxy butadienes to ethoxycarbamate 4 promoted by TMSOTf.