Tetrahedron Letters p. 1927 - 1930 (1989)
Update date:2022-08-11
Topics:
Knorr, Reinhard
Trzeciak, Arnold
Bannwarth, Willi
Gillessen, Dieter
2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) has been applied as coupling reagent to solid phase peptide synthesis.Furthermore, a general synthetic procedure for new derivatives of different N-hydroxy compounds has been developed.They either act as excellent activating reagents causing low racemization during condensation of peptide segments or are useful tools for the formation of active esters suitable for couplings in mixed aqueous / organic media, respectively.
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