Chemoselective formation of symmetrically linked bisisoxazole units: Steps toward isoxazoline/isoxazolidine based macrocycles

Article abstract of DOI:10.1016/0040-4039(96)00886-6

Symmetrically linked bisisoxazole derivatives can be formed from a chemoselective one-pot three component reaction between oximes, dipole generating and dipole trapping components. The use of bifunctional dipole generating moieties affords bisisoxazolines (11), linked through their N- atoms. The employment of bifunctional dipolarophitic agents leads to bisisoxazolidines (3 and 4) linked via their C-5 carbon atoms.