Development of 3,5-Di- tert -butylphenol as a Model Substrate for Biomimetic Aerobic Copper Catalysis

Article abstract of DOI:10.1055/s-0036-1588761

We develop 3,5-di- tert butylphenol as a strategic substrate for the evaluation of biomimetic Cu ₂ -O ₂ complexes intended to mimic the activity of tyrosinase. We describe a practical and scalable synthesis and validate its use in an aerobic ortho -oxygenation catalyzed by N, N ′-di- tert -butylethylenediamine and [Cu(CH ₃ CN) ₄ ]PF ₆.