SHORT- STEP SYNTHESIS OF AMINO ACIDS AND N-HYDROXYAMINO ACIDS FROM AMINES

Article abstract of DOI:10.1016/S0040-4039(00)96890-4

Catalytic oxidation of secondary amines with hydrogen peroxide followed by treatment with hydrogen cyanide gave α-cyanohydroxylamines (1).Hydrolysis of 1 gave N-hydroxyamino acids (2), which undergo catalytic hydrogenation to give amino acids (3).This is a simple, efficient, and inexpensive method for synthesis of amino acids from amines.