Enantioselective acylation of β-aminoesters using penicillin G acylase in organic solvents

Article abstract of DOI:10.1016/S0040-4039(99)00554-7

The resolution of racemic β-aminoesters has been achieved through selective acylation catalyzed by Penicillin G Acylase (ChiroCLEC(TM)-EC). The method has been optimized using three different phenylacetyl donors, and the effect of solvents on the rate of reaction is described. The efficiency of our method is illustrated by the synthesis of five different β-aminoesters with high enantiomeric purities.