Amino-chloro-pyridinecarboxaldehydes 23
The solid material was filtered off, washed twice with ethyl acetate
and the organic phase was concentrated to give the crude product
which was further purified by silica gel column chromatography
(hexane/ethyl acetate, 3:1). The product is a yellow solid; mp 165–
167°C; H NMR (CDCl3): δ 7.76 (s, 1H), 9.25 (s, 1H), 10.50 (s,
1H).
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1
5-Amino-2-chloro-4-pyridinecarboxaldehyde (1b)
Pettit, G. R.; Hoffmann, H.; McNulty, J.; Higgs, K. C.; Murphy,
A.; Molloy, D. J.; Herald, D. L.; Williams, M. D.; Pettit, R. K.;
Doubek, D. L.; et al. Antineoplastic agents. 380. Isolation and
X-ray crystal structure determination of isoaaptamine from the
Republic of Singapore hymeniacidon sp. and conversion to the
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Compound 1b was synthesized from compound 9 using the reported
procedure (Smith and Opie, 1948).
Acknowledgements
We are grateful for the generous financial supports from the
Scientific Research Project of Department of Education of
Liaoning Province of China (L2010048) and Key Laboratory of
Pesticide Chemistry and Application, Ministry of Agriculture
(MOAPCA201006).
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Received March 16, 2011; accepted April 20, 2011
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