Journal of Fluorine Chemistry p. 47 - 60 (1988)
Update date:2022-08-10
Topics:
Maki, Yasuo
Kimoto, Hiroshi
Fujii, Shozo
Senga, Munehiro
Cohen, Louis A.
The title condensations provide the corresponding (1'-hydroxy-2',2',2'-trifluoroethyl)indoles.Indole itself, 1-methylindole and 2-methylindole gave 3-adducts in yields of 77percent, 49percent and 84percent, respectively. 3-Substituted indoles (3-methylindole, ethyl indole-3-acetate and indole-3-ethyl acetate) afforded 2-adducts in yields of 69percent, 21percent and 23percent, respectively.The indole adduct eliminates water at 137 deg C to form a transient 3-(trifluoromethylmethylene)indolenine, which reacts rapidly with nucleophiles including indole.
View Morewebsite:http://www.win-winchemical.com
Contact:0086-577-64498589
Address:6F,No.396 Xingping Road,Longwan Industrial Zone
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Contact:+86-21-5161 3915
Address:Shanghai YangPu
Sichuan Sangao Biochemical Co., Ltd
Contact:+86-28-84874233
Address:19F, Bldg.2, Shudu Center, Tianfu 2nd St., Hi-tech zone, Chengdu 610041, Sichuan Province, China.
Shanghai Bocimed Pharmaceutical Co., Ltd.
website:http://www.bocimed.com
Contact:+86-21-68861632
Address:Building 1, Lane 647, Songtao Road, Zhangjiang High-Tech Park, Shanghai
website:http://www.orchid-chem.com
Contact:+86-571-85395792
Address:607, North Zhongshan Road, Hangzhou 310000 China
Doi:10.1039/F29807600711
()Doi:10.1039/C8NJ05671D
(2019)Doi:10.1016/0040-4039(95)01561-U
(1995)Doi:10.1246/cl.1997.245
(1997)Doi:10.1002/anie.201300292
(2013)Doi:10.1021/jf00057a024
(1995)