Study of an efficient and selective bromination reaction of substituted thiophenes

Article abstract of DOI:10.1080/00397919908086142

Bromination in concentrated solutions of substituted thiophenes in acetic acid with NBS at room temperature was studied. Under the conditions, bromination readily took place with high regioselectivity at the 2-ring positions, > 99%. The developed method was demonstrated to be suitable for multimolar preparations.

Full text of DOI:10.1080/00397919908086142

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Study of an Efficient and
Selective Bromination Reaction
of Substituted Thiophenes
Kenneth J. Hoffmann a & Per H.J. Carlsen a
a Department of Organic Chemistry, Norwegian
University of Science and Technology, N-7034,
Trondheim, Norway
Version of record first published: 17 Sep 2007.
To cite this article: Kenneth J. Hoffmann & Per H.J. Carlsen (1999): Study of an
Efficient and Selective Bromination Reaction of Substituted Thiophenes, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 29:9, 1607-1610
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