Tetrahedron Letters p. 1247 - 1250 (1988)
Update date:2022-08-11
Topics:
Bures, J. Edward
Keay, A. Brian
4-Lithio-2-(t-butyldimethylsilyl)-3-(hydroxymethyl)furan, generated by treating 2-(t-butyldimethylsilyl)-3-(hydroxymethyl)furan 2 with 2.2 equivalents of n-butyllithium (DME/0 deg C/15 min), is trapped by a variety of electrophiles to produce, after desilylation, 3,4-disubstituted furans in good to moderate yields.
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