Direct Ni° mediated synthesis of ketones from acyl bromides and Grignard reagents

Article abstract of DOI:10.1016/0040-4039(95)01936-C

A catalytic amount of NidppeCl₂ converts an acyl bromide directly into ketones at 0°C in THF in the presence of a Grignard reagent. The described procedure represents a useful way to afford dialkyl, diaryl or alkyl aryl ketones as well as 1,2-diketones. In the adopted reaction conditions double bonds, esters and ketones are unaffected.