Bioorganic and Medicinal Chemistry Letters p. 3089 - 3092 (2016)
Update date:2022-08-11
Topics:
Zhang, Xing
Khalidi, Omar
Kim, So Young
Wang, Ruitong
Schultz, Victor
Cress, Brady F.
Gross, Richard A.
Koffas, Mattheos A.G.
Linhardt, Robert J.
A series of 5,7-dihydroxyflavanone derivatives were efficiently synthesized. Their antimicrobial efficacy on Gram-negative, Gram-positive bacteria and yeast were evaluated. Among these compounds, most of the halogenated derivatives exhibited the best antimicrobial activity against Gram-positive bacteria, the yeast Saccharomyces cerevisiae, and the Gram-negative bacterium Vibrio cholerae. The cytotoxicities of these compounds were low as evaluated on HepG2 cells using a cell viability assay. This study suggests that halogenated flavanones might represent promising pharmacological candidates for further drug development.
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