Tetrahedron Letters p. 729 - 732 (1998)
Update date:2022-08-11
Topics:
Chen, Bang-Chi
Quinlan, Sandra L.
Reid, J. Gregory
Spector, Richard H.
The anti-AIDS drug d4T was prepared without contamination of the nucleoside bond cleaved by-product thymine from the readily available ribonucleoside 5-methyluridine (1). This was accomplished by using a new strategy which involved a regio/stereo controlled β-elimination of trans-bromoacetates 6.
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