Photo-triggered selective C-terminal N-methylamidative cleavage of polyethyleneglycol-bound peptides

Article abstract of DOI:10.1016/0040-4039(96)01363-9

A novel liquid-phase method has been designed for the photolytic release of the attached peptides, directly as their C-terminal N-methylamides, under mild conditions in excellent yields and purity. The present approach provides fully side-chain protected peptide N-methylamides, useful for segment condensation and facilitate photocontrolled release of biologically active peptides for therapeutic applications.