Enantio- and diastereoselective synthesis of N-[(1R,2R,3R,4R)-2,3- diacetoxy-4-(acetoxymethyl)cyclopentyl]acetamide, a synthetic key intermediate of (+)-cyclaradine

DOI: 10.1248/cpb.46.842

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 842 - 845 (1998)

Update date:2022-08-25

Topics:

Authors:

Norimine, Yoshihiko

Hayashi, Masaki

Tanaka, Masakazu

Suemune, Hiroshi

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Article abstract of DOI:10.1248/cpb.46.842

Enantio- and diastereoselective synthesis of N-[(1R,2R,3R,4R)-2,3- diacetoxy-4-(acetoxymethyl)cyclopentyl]acetamide 1, a synthetic key intermediate of (+)-cyclaradine, has been achieved by using enzyme-catalyzed asymmetric hydrolysis and subsequent modification of a functional group.

Full text of DOI:10.1248/cpb.46.842

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Product name:1,2-Cyclopentanediol, 3-amino-5-(hydroxymethyl)-, (1R,2R,3R,5R)-

Cas No:123880-25-1

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