CINETIQUE ET MECHANISME DE LA REACTION DE KNOVENAGEL DANS LE BENZENE-1 REACTION DU MALONITRILE ET DE LA (+) METHYL-3 CYCLOHEXANONE EN PRESENCE D'AMINES TERTIAIRE ET SECONDAIRE PURES OU EN MELANGE AVEC DES ACIDES CARBOXYLIQUES

Article abstract of DOI:10.1016/S0040-4020(01)91879-4

The kinetics of the reaction of malonitrile with (+) 3-methyl-cyclohexanone were studied in benzene at 25 deg C in the presence of triethylamine or piperidine, either alone or together with acetic acid or benzoic acid.The rate law of the reaction was found to be: v=k (Amine)(Ketone)(Nitrile).It is interpreted in terms of a basic catalysis by the amine.When amine-acid mixtures were used, a general acid catalysis was observed but its effect on the overall rate of the reaction was slight, since the acid also lowered the concentration of free amine.