Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site

DOI: 10.1021/jm00168a011

Source and publish data:

Journal of Medicinal Chemistry p. 1594 - 1600 (1990)

Update date:2022-08-17

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Authors:

Hibert Hibert

Hoffmann

Miller Miller

Carr Carr

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Article abstract of DOI:10.1021/jm00168a011

A conformation-activity relationship study of 5-HT₃ receptor antagonists was used to define a pharmacophore and receptor map to qualitatively account for their activity. The design and synthesis of specific keto-amino-indole derivatives that are potent 5-HT₃ receptor antagonists gave some support to the model.

Full text of DOI:10.1021/jm00168a011

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