Journal of Medicinal Chemistry p. 1594 - 1600 (1990)
Update date:2022-08-17
Topics:
Hibert
Hoffmann
Miller
Carr
A conformation-activity relationship study of 5-HT3 receptor antagonists was used to define a pharmacophore and receptor map to qualitatively account for their activity. The design and synthesis of specific keto-amino-indole derivatives that are potent 5-HT3 receptor antagonists gave some support to the model.
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(1982)
