A convenient synthesis of chiral oxazolidin-2-ones and thiazolidin-2-ones and an improved preparation of triphosgene

Article abstract of DOI:10.1080/00397919308012605

Oxazolidin-2-ones and thiazolidin-2-ones are conveniently prepared by condensation of L-serine, L-threonine and L-cysteine, respectively with triphosgene. The corresponding methyl esters may be subsequently obtained by quenching the reaction mixture with methanol, without prior need for the isolation of the free acids. An improved procedure for preparation of triphosgene using an internal cooling system is described.

Full text of DOI:10.1080/00397919308012605

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Synthetic Communications: An
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A Convenient Synthesis of
Chiral Oxazolidin-2-Ones
and Thiazolidin-2-Ones and
an Improved Preparation of
Triphosgene
Eliezer Falb a , Abraham Nudelman a & Alfred
Hassner a
a Chemistry Department, Bar Ilan University, Ramat
Gan, 52900, Israel
Version of record first published: 23 Sep 2006.
To cite this article: Eliezer Falb , Abraham Nudelman & Alfred Hassner (1993): A
Convenient Synthesis of Chiral Oxazolidin-2-Ones and Thiazolidin-2-Ones and an
Improved Preparation of Triphosgene, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 23:20, 2839-2844
To link to this article: http://dx.doi.org/10.1080/00397919308012605
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