Tetrahedron Letters p. 7493 - 7496 (1993)
Update date:2022-08-17
Topics:
Clayton, Simon C.
Regan, Andrew C.
A total synthesis of the potent non-opiate analgesic alcaloid epibatidine is described, in which the key step is reductive palladium-catalysed Heck-type coupling.The synthesis is concise (two steps from known compounds), highly convergent, and completely sttereoselective for the desired exo-isomer. - Key Words: Epibatidine, Analgesic, Alkaloid, Palladium-catalysed Coupling
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