New Chiral Anisotropic Reagents for Determining the Absilute Configuration of Carboxylic Acids

Article abstract of DOI:10.1016/0040-4039(95)00132-V

Enantiomers of phenylglycine dimethylamide (PGDA) and phenylglycine methyl ester (PGME) were prepared as the reagents for determining the absolute configuration of carboxyl acids of type I.Each enantiomer of PGDA and PGMA was condensed with several carbixylic acids, the absolute configuration of which is known.The absolute configuration of the carboxylic acids, predicted by Δδ values (Δδ = δ_S - δ_R) of the protons and Model B, is the same as the known one without exception.