Asymmetric reductions of (Trifluoroacetyl)biphenyl derivatives with bakers'yeast and with Geotrichum candidum acetone powder

Article abstract of DOI:10.1016/S0040-4020(98)00144-6

The bakers' yeast reduction of (trifluoroacetyl)biphenyl derivatives produces (R)trifluoromethyl biphenylyl carbinols in high enantioselectivity, whereas the reduction of the same derivatives with Geotrichum candidum acetone powder gives the corresponding (S)-carbinols in excellent yields and enantioselectivity.