Enantioselective hydrolysis of nitriles and amides using an immobilised whole cell system

DOI: 10.1016/S0957-4166(00)86056-5

Source and publish data:

Tetrahedron Asymmetry p. 1543 - 1546 (1992)

Update date:2022-08-11

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Authors:

Cohen Cohen

Parratt Parratt

Turner Turner

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Article abstract of DOI:10.1016/S0957-4166(00)86056-5

An immobilised whole cell catalyst SP361 has been shown to hydrolyse a range of 2-alkyl arylacetonitriles 1a-3a and amides 2b, 3b with good to excellent enantioselectivity. The absolute configuration of the derived amides and/or carboxylic acids shows remarkable changes according to the structure of the nitrile substrate.

Full text of DOI:10.1016/S0957-4166(00)86056-5

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