Journal of Organic Chemistry p. 5747 - 5750 (1991)
Update date:2022-08-16
Topics:
Walker, Michael A.
Heathcock, Clayton H.
The Evans reagent, imide 1, reacts with aldehydes under Lewis acid catalysis to give anti or "non-Evans" syn aldols 5 or 6, depending on the reaction conditions.This discovery considerably amplifies the synthetic utility of these important reagents for asymmetric synthesis.
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