Straightforward synthesis of N-protected benzylic amines by carbamoalkylation of aromatic compounds

Article abstract of DOI:10.1016/S0040-4039(98)02578-7

A wide range of alkoxycarbonyl protected benzylic amines have been synthesized in a three component reaction involving a carbamate an aldehyde and an aromatic substrate. This reaction proceeds through electrophilic substitution of the aromatic compound by a N-carbamoyl iminium which is generated in situ by condensation of the carbamate with the aldehyde.