Carboxylation of Active Methylene Compounds Using Anilide, Potassium Carbonate, and Carbon Dioxide

Article abstract of DOI:10.1246/bcsj.67.452

Active methylene compounds were effectively carboxylated with carbon dioxide in the presence of anilide (acetanilide or formanilide) and potassium carbonate at 20-40 deg C for 0.5-10 h.In the carboxylation of fluorene, a high yield (48percent) was obtained at 20 deg C for 4 h.The yield of carboxylic acid using 2,6-dimethylacetanilide was 8.9percent, and smaller than 26.6percent when using acetanilide at 20 deg C for 2 h, indicating the interference of a methyl group for the carboxylation.