Enzyme-Catalyzed Organic Synthesis: Electrochemical Regeneration of NAD(P)H from NAD(P) Using Methyl Viologen and Flavoenzymes

DOI: 10.1021/jo00335a078

Source and publish data:

Journal of Organic Chemistry p. 4622 - 4623 (1981)

Update date:2022-08-11

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Authors:

DiCosimo, Robert

Wong, Chi-Huey

Daniels, Lacy

Whitesides, George M.

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Article abstract of DOI:10.1021/jo00335a078

A procedure for enzyme-catalyzed organic synthesis is described in which regeneration of NAD(P)H from NAD(P) is accomplished by the electrochemical reduction of oxidized to reduced methyl viologen (MV²⁺ --> MV¹⁺) followed by flavoenzyme-catalyzed reduction of the nicotinamide cofactor by this MV⁺¹ (Scheme I).

Full text of DOI:10.1021/jo00335a078

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