A Novel Class of Cyclic β-Dicarbonyl Leaving Groups and Their Use in the Design of Benzisothiazolone Human Leukocyte Elastase Inhibitors

DOI: 10.1021/jm00023a008

Source and publish data:

Journal of Medicinal Chemistry p. 4687 - 4692 (1995)

Update date:2022-08-04

Topics:

Authors:

Hlasta, Dennis J.

Ackerman, James H.

Court, John J.

Farrell, Robert P.

Johnson, Judith A.

et al. et al.

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Article abstract of DOI:10.1021/jm00023a008

Human leukocyte elasatase (HLE) has been proposed to be a primary mediator of plumonary emphysema, and inhibitors of this enzyme should be effective in the treatment of emphysema and other plumonary diseases.We have discovered a novel class of alicyclic a

Full text of DOI:10.1021/jm00023a008

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