A Simple, One-Pot Synthesis of 1-Alkoxy-1-alkynes and 1-Alkoxy-1-alkyn-3-ols

Article abstract of DOI:10.1055/s-1988-27545

The title compound are prepared by a high yield, one-pot reaction using readily available chloroacetaldehyde dialkyl acetals as starting materials.The reaction is initiated by sodium amide and the intermediate acetylide anion thus produced, reacts readily with a variety of electrophiles such as alkyl halides, carbonyl compounds or water to produce the desired products.