Stereoselective Addition of Organoaluminium or Organomanganese Reagents to 2-Methyl-3-oxo Amides (or Esters) Providing erythro or threo 2-Methyl-3-hydroxy Amides (or Esters)

Article abstract of DOI:10.1016/S0040-4039(00)74258-4

Treatment of 2-methyl-3-oxo amides or 2-methyl-3-oxo esters with trialkylaluminium or alkylmanganese halide provided the corresponding erythro (or threo) 3-hydroxy-2-methyl amides or 3-hydroxy-2-methyl esters with high stereoselectivity.