Chemistry Letters p. 247 - 250 (1992)
Update date:2022-08-11
Topics:
Smith, Michael B.
Wang, Chung-Jen
Keusenkothen, Paul F.
Dembofsky, Bruce T.
Fay, Joseph G.
et al.
N-Alkenyl and N-alkoxymethyl lactams are impervious to many reagents and are useful protecting groups for lactams.Conversion to the corresponding 2-ethoxy iminium salt and hydrolysis in neutral water removes the protecting group.Mild basification regenerates the lactam.
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