Synthetic approaches to 2-pyrrolidinone-5-carboxaldehyde

Article abstract of DOI:10.1080/00397919608004620

We have examined routes for the preparation of 2-pyrrolidinone-5S-carboxaldehyde which include oxidation of 5-hydroxymethyl-2-pyrrolidinone and reduction of 5-oxoproline ethyl ester. Only the oxidation route proved satisfactory. Moffatt oxidation was most efficient but PCC oxidation gave modest yields of the desired aldehyde.

Full text of DOI:10.1080/00397919608004620

This article was downloaded by: [130.132.123.28]
On: 30 December 2014, At: 13:27
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954
Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH,
UK
Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/lsyc20
Synthetic Approaches
to 2-Pyrrolidinone-5-
carboxaldehyde
a
a
Jeffrey Deskus , Michael B. Smith & Tiberiu
a
Simandan
a
Department of Chemistry , University of
Connecticut , Storrs, Room 151, 215 Glenbrook
Road, Connecticut , 06269-3060
Published online: 21 Aug 2006.
To cite this article: Jeffrey Deskus , Michael B. Smith & Tiberiu Simandan
(1996) Synthetic Approaches to 2-Pyrrolidinone-5-carboxaldehyde, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 26:16, 3137-3150, DOI: 10.1080/00397919608004620
To link to this article: http://dx.doi.org/10.1080/00397919608004620
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the
information (the “Content”) contained in the publications on our platform.
However, Taylor & Francis, our agents, and our licensors make no
representations or warranties whatsoever as to the accuracy, completeness,
or suitability for any purpose of the Content. Any opinions and views
expressed in this publication are the opinions and views of the authors, and
are not the views of or endorsed by Taylor & Francis. The accuracy of the
Content should not be relied upon and should be independently verified with

primary sources of information. Taylor and Francis shall not be liable for any
losses, actions, claims, proceedings, demands, costs, expenses, damages,
and other liabilities whatsoever or howsoever caused arising directly or
indirectly in connection with, in relation to or arising out of the use of the
Content.
This article may be used for research, teaching, and private study purposes.
Any substantial or systematic reproduction, redistribution, reselling, loan,
sub-licensing, systematic supply, or distribution in any form to anyone is
expressly forbidden. Terms & Conditions of access and use can be found at
http://www.tandfonline.com/page/terms-and-conditions