A simple method of protecting a secondary amine with tert butyloxycarbonyl (BOC) in the presence of a primary amine

Article abstract of DOI:10.1080/00397919208019091

A simple method for chemically differentiating primary and secondary amines is described in which the primary amine is condensed with benzaldehyde to form an imine leaving the secondary amine available to be protected with BOC. The imine is then hydrolyze

Full text of DOI:10.1080/00397919208019091

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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A Simple Method of Protecting
a Secondary Amine with Tert
Butyloxycarbonyl (Boc) in the
Presence of a Primary Amine
a
a
John D. Prugh , Laura A. Birchenough & Melissa S.
a
Egbertson
a
Department of Medicinal Chemistry, Merck
Research Laboratories West Point, Pennsylvania,
19486
Published online: 23 Sep 2006.
To cite this article: John D. Prugh , Laura A. Birchenough & Melissa S. Egbertson
(
(
1992): A Simple Method of Protecting a Secondary Amine with Tert Butyloxycarbonyl
Boc) in the Presence of a Primary Amine, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 22:16, 2357-2360
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