Design and Synthesis of Some Substrate Analogue Inhibitors of Phospholipase A2 and Investigations by NMR and Molecular Modeling into the Binding Interactions in the Enzyme-Inhibitor Complex

Article abstract of DOI:10.1021/jm00094a003

A series of substrate analogue inhibitors of pancreatic phospholipase A₂ has been designed and synthesized.The compounds were tested in a novel dual-screening system based on parallel assays with monomeric and micellar substrates.Intermolecular