Design and Synthesis of Some Substrate Analogue Inhibitors of Phospholipase A2 and Investigations by NMR and Molecular Modeling into the Binding Interactions in the Enzyme-Inhibitor Complex

DOI: 10.1021/jm00094a003

Source and publish data:

Journal of Medicinal Chemistry p. 2939 - 2951 (1992)

Update date:2022-07-29

Topics:

Authors:

Bennion, Colin

Connolly, Stephen

Gensmantel, Nigel P.

Hallam, Catherine

Jackson, Clive G.

et al. et al.

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Article abstract of DOI:10.1021/jm00094a003

A series of substrate analogue inhibitors of pancreatic phospholipase A₂ has been designed and synthesized.The compounds were tested in a novel dual-screening system based on parallel assays with monomeric and micellar substrates.Intermolecular

Full text of DOI:10.1021/jm00094a003

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