Design and Synthesis of Some Substrate Analogue Inhibitors of Phospholipase A2 and Investigations by NMR and Molecular Modeling into the Binding Interactions in the Enzyme-Inhibitor Complex

DOI: 10.1021/jm00094a003

Source and publish data:

Journal of Medicinal Chemistry p. 2939 - 2951 (1992)

Update date:2022-07-29

Topics:

Authors:

Bennion, Colin

Connolly, Stephen

Gensmantel, Nigel P.

Hallam, Catherine

Jackson, Clive G.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00094a003

A series of substrate analogue inhibitors of pancreatic phospholipase A₂ has been designed and synthesized.The compounds were tested in a novel dual-screening system based on parallel assays with monomeric and micellar substrates.Intermolecular

Full text of DOI:10.1021/jm00094a003

Products guided by the article

Product name:Hexadecanamide, N-[2-phenyl-1-[(phosphonooxy)methyl]ethyl]-, (R)-

Cas No:142003-47-2

R&D Labs maybe for 142003-47-2

Hangzhou TJM Chemical Trade Co., Ltd

Contact:86-571-88223276 86-13388481653

Address:2221#,Boyuexuan,1860# Binsheng Road,Binjiang District, Hangzhou CityZhejiang Province, 310051, P. R. China
Shanghai AoBo Bio-Pharmaceutical Technology Co., Ltd.

Contact:+86-21-51320130-801, 816

Address:Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Pudong, Shanghai
Yancheng Smiling Imp & Exp Co., Ltd.

Contact:+86-515-83173586

Address:Rm1207, BLD#03, Phoenix Plaza, Juheng Road, Yancheng, Jiangsu, P.R. China
Shanghai Dynamic Industrial Co.,Ltd.

website:http://www.shdynamic.com

Contact:86-021 3392 6680

Address:Room 805 Information Tower, No.1403 Minsheng Road, Pudong New Area, Shanghai 200135, P. R. China
Taizhou KEDE Chemical.Co.,Ltd.

Contact:86-576-84613060

Address:Jiangkou Chemical Zoon

Relevant to this article

Facile preparation of 2-arylbenzoselenazoles from three components reactions: 2-Chloronitrobenzene, Se, and arylacetic acids

Doi:10.1016/j.tetlet.2019.151393
(2020)
Coupling of amines, dialkyl acetylenedicarboxylates and formaldehyde promoted by [n-Bu₄N][HSO₄]: An efficient synthesis of highly functionalized dihydro-2-oxopyrroles and bis-dihydro-2-oxopyrroles

Doi:10.1007/s11164-012-0998-7
(2014)
Octupolar derivatives functionalized with superacceptor peripheral groups: Synthesis and evaluation of the electron-withdrawing ability of potent unusual groups

Doi:10.1002/chem.201103460
(2012)
Blue: Versus yellow emission in bipolar fluorenone derivatives: The impact of aggregation and hydrogen bonding

Doi:10.1039/c7tc05798a
(2018)
N'-Alkylaminosulfonyl Analogues of 6-Fluorobenzylideneindolinones with Desirable Physicochemical Profiles and Potent Growth Inhibitory Activities on Hepatocellular Carcinoma

Doi:10.1002/cmdc.201500235
(2015)
Synthesis and biological activity of some 3-[(4-Amino-5-thioxo-1,2,4- triazol-3-yl)methyl]benzothiazol-2(3H)-one Derivatives

Doi:10.14233/ajchem.2013.12903
(2013)

Article Doi