Journal of Antibiotics p. 788 - 793 (1996)
Update date:2022-08-10
Topics:
Johnson, Roy A.
Marshall, Vincent P.
Li, Grace P.
Sih, John C.
Cialdella, Joyce I.
Liggett, Walter F.
Nidy, Eldon G.
Oxygenation of pioglitazone-N-oxide by a microorganism isolated from soil was accompanied by N-deoxygenation to produce the pioglitazone metabolites 5-[4-[2-[5-(1-hydroxyethyl)-2-pyridyl]ethoxy]benzyl]-2,4-thiazolidinedione and 5-[4-[2-(5-acetyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione. The oxygenating/deoxygenating organism has been characterized as Streptomyces hygroscopicus strain 02179 (UC 11099). The culture has been deposited with Agricultural Research Service, USDA, with accession number NRRL 18975.
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