Chemoenzymatic synthesis of 'α-bichiral' synthons. Application to the preparation of chiral epoxides

Article abstract of DOI:10.1016/S0957-4166(00)80239-6

Microbiological reduction of 3-bromo-2-octanone and 3-azido-2-octanone led to all the stereoisomers of 3-bromo-2-octanol and 3-azido-2-octanol. Chiral 2,3-epoxyoctanes were prepared from the 3-bromo-2-octanols.