Journal of the Chemical Society. Chemical communications p. 1651 - 1654 (1987)
Update date:2022-08-17
Topics:
Baldwin, Jack E.
Adlington, Robert M.
Aplin, Robin T.
Crouch, Nicholas P.
Knight, Graham
Schofield, Christopher J.
Incubation of <3-2H> penicillin N with preparations of deacetoxycephalosporin C/deacetylcephalosporin C synthetase activity from Cephalosporium acremonium CO 728 gave, along with the normal product deacetoxycephalosporin C, another β-lactam metabolite, namely 7β-<(R)-5-amino-5-carboxypentanoyl>-3β-hydroxy-3α-methyl<4-2H)-cepham-4α-carboxylic acid.This material arises as a result of a deuterium isotope effect on a branched pathway in the enzymic mechanism.The 3β-hydroxy group in this substance arises from molecular oxygen.
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